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KMID : 0357920010350050376
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Korean Journal of Pathology
2001 Volume.35 No. 5 p.376 ~ p.382
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β-Catenin Expression in Gastric Carcinogenesis
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Kang Hae-Youn
Choi Yon-Rak
Kim Ho-Guen
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Abstract
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Background: The molecular pathogenesis of gastric carcinoma is not yet well characterized. The purpose of this study is to assess the role of β-catenin in gastric carcinogenesis.
Methods: We analyzed β-catenin expression using immunohistochemistry on 68 gastric adenomas and 34 gastric adenocarcinomas, and compared the result with pathological and molecular types of tumors and E-cadherin expression.
Results: Nuclear expression of β-catenin was noted more frequently in gastric adenomas than in carcinomas (40% vs. 21%, 0.05≤p<1). There was no significant relationship between nuclear β-catenin expression and histologic degree of adenoma, histologic type of carcinoma or microsatellite instability. E-cadherin expression showed significantly more frequent decrease in the membrane stainability of carcinomas compared to adenomas (p<0.01).
Conclusions: The frequent nuclear β-catenin expression in gastric adenomas suggests that the β-catenin alteration might play an early role in gastric carcinogenesis.
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KEYWORD
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Stomach neoplasms, Beta catenin, Cadherins, Microsatellite repeats
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